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. 2019 May 10;19:126. doi: 10.1186/s12935-019-0848-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — UBN2 inhibition suppresses CRC Proliferation and Metastasis via the Ras/MAPK Signaling Pathway. a The expression of UBN2, KRAS, Rac1/2/3, total ERK, phosphorylated ERK, cyclinD1, p21 and p27 in vector-infected (NC) and UBN2 siRNA-infected (UBN2-S1, UBN2-S2) CRC cell lines were detected by Western blotting. b Real-time RT-PCR analyses of cyclinD1, p21, and p27 were performed in the indicated CRC cell lines. Error bars represent mean ± SD from 3 independent experiments. c A model for UBN2 regulation of tumorigenesis. *p < 0.05, **p < 0.01