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. 2019 May 10;12:43. doi: 10.1186/s13048-019-0519-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic of the experimental design. Mouse granulosa cells were collected from the ovaries of immature female mice and then treated with PA, PA + melatonin, PA + 4-PBA or TG + melatonin to explore the mechanism of melatonin that protects against PA-induced cell apoptosis