Table 2.
Detailed pathologic features for patients with or without renal endpoints
| Pathologic features | Renal endpoints reached | P value | |
|---|---|---|---|
| Yes | No | ||
| Mesangial hypercellularity a, n (%) | 0.238 | ||
| Normal | 0 | 2 (0.4) | |
| Mild | 26 (86.7) | 207 (84.5) | |
| Moderate | 3 (10.0) | 35 (14.3) | |
| Severe | 1 (3.3) | 1 (0.4) | |
| tubulointerstitial inflammation a,b, n (%) | 0.004 | ||
| Absent | 4 (13.3) | 68 (27.7) | |
| ≤25% | 12 (40.0) | 133 (54.3) | |
| >25% and ≤ 50% | 6 (20.0) | 12 (4.9) | |
| >50% | 8 (26.7) | 32 (13.1) | |
| Proportion of glomeruli per biopsy | |||
| Segmental sclerosis (%)c | 3.4 (0, 16.7) | 2.0 (0, 7.5) | 0.098 |
| Crescents (%)c | 12.9 (3.5, 23.3) | 4.0 (0, 13.3) | <0.001 |
| Tubular atrophy (%)c | 5 (1, 15) | 5 (0, 5) | 0.013 |
The data was expressed as numbers (percentages)
aMesangial hypercellularity was assessed in semi- quantitative way: normal = 3 or less cells per mesangial area; mild = 4 or 5 cells per mesangial area; moderate = 6 or 7 cells per mesangial area; severe = 8 or more cells in mesangial area
bTubulointerstitial inflammation applied to inflammation in the biopsy overall (including areas of interstitial fibrosis/tubular atrophy)
cProportion of glomeruli per biopsy with lesion, data was expressed as median (interquartile range)