Table 1.
Definitions of comorbidities included in the augmented comorbidity/age index and their corresponding scores
| Comorbidity | Definition | Score | |
|---|---|---|---|
| HCT-CI | |||
| Arrhythmia | Any type of arrhythmia that has necessitated the delivery of a specific anti-arrhythmia treatment at any time point in the patient’s past medical history. | 1 | |
| Cardiac | Coronary artery disease,§ congestive heart failure, myocardial infarction, or EF ≤50% | 1 | |
| Inflammatory bowel disease | Crohn’s disease or ulcerative colitis requiring treatment at any time point in patient’s past medical history. | 1 | |
| Diabetes | Requiring treatment with insulin or oral hypoglycemic agents continuously for 4 weeks before start of conditioning | 1 | |
| Cerebrovascular disease | Transient ischemic attack or cerebrovascular accident | 1 | |
| Psychiatric disturbance | Any disorder requiring continuous treatments for 4 weeks before start of conditioning | 1 | |
| Hepatic, mild | Chronic hepatitis, bilirubin > ULN to 1.5 × ULN, or AST/ALT> ULN to 2.5 × ULN; at least two values of each within 2 or 4 weeks before start of conditioning. | 1 | |
| Obesity | Patients with a body mass index >35 kg/m2 for patients older than 18 years or a BMI-for-age of ≥ 95th percentile for patients of ≤ 18 years of age | 1 | |
| Infection | Requiring antimicrobial treatment starting from before conditioning and continued beyond day 0 | 1 | |
| Rheumatologic | Requiring specific treatment at any time point in the patient’s past medical history | 2 | |
| Peptic ulcer | Based on prior endoscopic or radiologic diagnosis | 2 | |
| Moderate/severe renal | Serum creatinine > 2 mg/dl (at least two values of each within 2 or 4 weeks before start of conditioning), on dialysis, or prior renal transplantation | 2 | |
| Moderate pulmonary | Corrected DLco (via Dinakara equation) and/or FEV1 of 66%–80% or dyspnea on slight activity | 2 | |
| Prior malignancy | Treated at any time point in the patient’s past history, excluding non-melanoma skin cancer | 3 | |
| Heart valve disease | Of at least moderate severity, prosthetic valve, or symptomatic mitral valve prolapse as detected by echocardiogram | 3 | |
| Severe pulmonary | Corrected DLco (via Dinakara equation) and/or FEV1 ≤ 65% or dyspnea at rest or requiring oxygen | 3 | |
| Moderate/severe hepatic | Liver cirrhosis, bilirubin > 1.5 × ULN, or AST/ALT > 2.5 × ULN; at least two values of each within 2 or 4 weeks before start of conditioning | 3 | |
| Augmented comorbidity/age index: all of the above plus | |||
| High ferritin | Values of ≥2500 as measured the closest prior to start of conditioning | 1 | |
| Mild hypoalbuminemia | Values of <3.5–3.0 as measured the closest prior to start of conditioning | 1 | |
| Moderate gypoalbuminemia | Values of < 3.0 as measured the closest prior to start of conditioning | 2 | |
| Thrombocytopenia | Values of <100,000 as measured the closest prior to start of conditioning | 1 | |
| Age | ≥40 years | 1 | |
Abbreviations: EF = ejection fraction; ULN= upper limit of normal; DLco= diffusion capacity of carbon monoxide: FEV1= forced expiratory volume in 1 second.
§
One or more vessel-coronary artery stenosis requiring medical treatment, stent, or bypass graft