Table 6.
Adjusted hazard ratios for nonrelapse mortality and overall survival as stratified by augmented comorbidity/age index comparing alternative graft sources
HR (95% CI) | p-value | Adjusted* HR (95% CI) | Adjusted* p-value | |
---|---|---|---|---|
Nonrelapse mortality with augmented comorbidity/age score <4 | ||||
Antigen mismatched | 1.0 | 1.0 | ||
Cord blood | 0.87 (0.55–1.38) | 0.56 | 0.98 (0.59–1.62) | 0.94 |
Haploidentical | 1.42 (0.82–2.47) | 0.21 | 1.24 (0.58–2.63) | 0.58 |
Nonrelapse mortality with augmented comorbidity/age score ≥4 | ||||
Antigen mismatched | 1.0 | 1.0 | ||
Cord blood | 1.06 (0.75–1.48) | 0.75 | 1.40 (0.88–2.24) | 0.16 |
Haploidentical | 1.18 (0.78–1.77) | 0.43 | 1.48 (0.82–2.66) | 0.19 |
Overall Survival with augmented comorbidity/age score <4 | ||||
Antigen mismatched | 1.0 | 1.0 | ||
Cord blood | 0.73 (0.52–1.04) | 0.08 | 0.84 (0.58–1.23) | 0.37 |
Haploidentical | 0.96 (0.61–1.51) | 0.86 | 0.99 (0.53–1.86) | 0.99 |
Overall survival with augmented comorbidity/age score ≥4 | ||||
Antigen mismatched | 1.0 | 1.0 | ||
Cord blood | 0.87 (0.65–1.17) | 0.36 | 0.94 (0.64–1.36) | 0.73 |
Haploidentical | 1.16 (0.83–1.63) | 0.38 | 1.20 (0.76–1.91) | 0.43 |
Adjusted for conditioning (myeloablative, reduced-intensity, or nonmyeloablative), age (<50, ≥50), cytomegalovirus serostatus (+, −), disease risk (low, high), and Karnofsky Performance Status score (≤80, >80)