Table 1:
Demographic characteristics of the 30 men contributing 60 urine samples in MARS by crossover arm.
| Baseline characteristics, men (N)a | B1H-arm (15 men, 30 samples) | H1B-arm (15 men, 30 samples) | Total (30 men, 60 samples) | P-value b |
|---|---|---|---|---|
| Age (Years) | 35.2 (8.63) | 34.5 (10.8) | 34.8 (9.60) | 0.63 |
| Race | 0.35 | |||
| Caucasian | 14 (93) | 12 (80) | 26 (87) | - |
| Black/African American | 1 (7) | 0 | 1 (3) | - |
| Asian | 0 | 1 (7) | 1 (3) | - |
| Other | 0 | 2 (13) | 2 (7) | - |
| BMI (Kg/m2) | 26.6 (3.68) | 24.3 (3.23) | 25.5 (3.59) | 0.08 |
| BMI-categories | 0.15 | |||
| Normal weight | 5 (33) | 9 (60) | 14 (47) | - |
| Overweight | 7 (47) | 6 (40) | 13 (43) | - |
| Obese | 3 (20) | 0 | 3 (10) | - |
| Education | 0.26 | |||
| Below college | 0 | 2 (14) | 2 (7) | - |
| College graduate | 9 (69) | 6 (43) | 15 (56) | - |
| Graduate degree | 4 (31) | 6 (43) | 10 (37) | - |
| Smoking status | 0.99 | |||
| Never smoker | 14 (93) | 14 (93) | 28 (93) | - |
| Former smoker | 1 (7) | 1 (7) | 2 (7) | - |
| Current smoker | 0 | 0 | 0 | - |
| IBD diagnosis | 0.99 | |||
| Ulcerative colitis | 11 (73) | 10 (67) | 21 (70) | - |
| Crohn’s disease | 4 (27) | 5 (33) | 9 (30) | - |
| IBD scored | 1.8 (1.42) | 0.93 (1.44) | 1.37 (1.47) | 0.07 |
| Duration since IBD diagnosis (years) | 10.5 (8.15) | 10.5 (7.50) | 10.5 (7.70) | 0.95 |
| Alcohole | 0.07 | |||
| < 1 days/week | 5 (36) | 8 (57) | 13 (46) | - |
| 1–2 days/week | 8 (57) | 2 (14) | 10 (36) | - |
| ≥2 days/week | 1 (7) | 4 (29) | 5 (18) | - |
| Time-varying characteristics, Samples (n)a | ||||
| Warm season of urine sample c | 11 (37) | 17 (57) | 28 (47) | 0.12 |
| Fever in last 3 months | 1 (3) | 0 | 1 (2) | 0.99 |
| Illness in last 3 months | 9 (33) | 4 (15) | 13 (25) | 0.20 |
Abbreviations: MARS, Mesalamine And Reproductive health Study; DBP, dibutyl phthalate; BMI, body mass index; Kg, Kilogram; m, meter; SD, standard deviation; IBD, Inflammatory Bowel Disease; UC, ulcerative colitis; CD, Crohn’s disease; N; number of men, CI; confidence interval.
B1H-arm: B1 represents background-exposure of DBP at baseline and H represents high-DBP exposure after crossover. H1B-arm: H1 represents high-DBP exposure at baseline and B represents background-exposure after crossover.
B1H arm: men at baseline were on Liald (N=10), Pentasa (N=4) and Apriso (N=1).
H1B arm: men at baseline were on Asacol (N=7), and Asacol-HD (N=8).
IBD score: included bowel frequency and urgency, presence of blood in the stool and general wellbeing. Mild IBD score: 5 or less on the simple clinical colitis activity index for UC and 4 or less on the Harvey-Bradshaw index for CD.
Season of sample collection, Warm: April through September.
3 missing education, 2 missing alcohol, 1 missing alcohol, and 7 missing illness in the last 3 months.
N (%) for categorical/binary variables and mean (SD) for continuous variables.
P-values are based on Fisher exact test for categorical variables and Kruskal Wallis test for continuous variables.