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. Author manuscript; available in PMC: 2020 May 11.
Published in final edited form as: Circulation. 2018 Nov 11;139(4):489–501. doi: 10.1161/CIRCULATIONAHA.118.035774

Figure 4. Association of suggestive all-cause heart failure and nonischemic cardiomyopathy variants with selected cardiac MRI traits of left ventricular structure and function in UK Biobank.

Figure 4.

Linear regression was used to test the association of suggestive signals for all-cause heart failure and nonischemic cardiomyopathy variants with measured cardiac MRI traits in up to 4,158 individuals free of clinical heart failure in the UK Biobank. Testing was performed using allelic dosages, adjusting for age at baseline, sex, genotyping chip, and the first 10 principal components of ancestry. Results are displayed for (a) rs2234962 near BAG3 and (b) rs10927875 near ZBTB17 against three selected cardiac MRI traits as no other variants had associations reaching statistical significance. Points represent the effect in SD units of each respective cardiac MRI trait and error bars denote 95% confidence intervals. Significant associations passing Bonferroni significance (P < 0.05 / 42 = 1.19×10−3) are denoted with a star (*). Abbreviations: NICM=nonischemic cardiomyopathy; β=effect per NICM risk allele in SD units of the cardiac MRI trait; SD=standard deviation.