Table 1.
Baseline characteristics of UK Biobank samples by heart failure status.
| All-cause HF (n = 7,382) |
NICM (n = 2,038) |
All-cause HF vs. NICM P-value |
Referents free of all-cause HF (n = 480,628) |
|
|---|---|---|---|---|
| Age at baseline, years | 62.2 (6.3) | 61.6 (6.7) | < 0.001 | 57.0 (8.1) |
| Male gender, n (%) | 5,151 (69.8%) | 1,324 (65.0%) | < 0.001 | 218,203 (45.4%) |
| UK BiLEVE array, n (%) | 1,071 (14.5%) | 274 (13.4%) | 0.12 | 48,830 (10.2%) |
| Height, cm | 170.3 (9.4) | 170.8 (9.6) | 0.003 | 168.5 (9.3) |
| Body mass index, kg/m2 | 29.8 (5.8) | 29.3 (5.9) | < 0.001 | 27.4 (4.8) |
| Waist-hip ratio | 0.94 (0.09) | 0.92 (0.09) | < 0.001 | 0.87 (0.09) |
| Systolic blood pressure, mmHg | 148.5 (22.4) | 147.5 (22.2) | 0.02 | 140.9 (20.7) |
| Diastolic blood pressure, mmHg | 86.5 (12.2) | 86.8 (12.2) | 0.19 | 84.3 (11.3) |
| Coronary Artery Disease, n (%) | 3,491 (47.3%) | 0 (0.0%) | NA | 19,726 (4.1%) |
| Type 2 DM, n (%) | 1,929 (26.1%) | 395 (19.4%) | < 0.001 | 22,515 (4.7%) |
| Atrial Fibrillation, n (%) | 3,172 (43.0%) | 1,036 (50.8%) | < 0.001 | 14,498 (3.0%) |
| Hypertension, n (%) | 5,584 (75.6%) | 1,413 (69.3%) | < 0.001 | 153,369 (31.9%) |
Values are presented as mean (standard deviation) unless otherwise noted. Baseline characteristics of NICM samples (n = 2,038) were compared to all-cause heart failure samples without NICM (n = 5,344) using a standard t-test for continuous measures and chi-square test for dichotomous traits. Abbreviations: HF=heart failure; NICM=nonischemic cardiomyopathy; DM=diabetes mellitus.