Table 2.

Replication of suggestive signals from genetic association analyses for all-cause heart failure in UK Biobank.

					UK Biobank (n cases=6,504)			BioVU Study (n cases=2,982)			GRADE (n cases=1,060)
Rsid	Chr	Pos	Nearest Gene	RA/ NRA	RAF	OR (95% CI)	P-value	RAF	OR (95% CI)	P-value	RAF	OR (95% CI)	P-value
rs1906609	4	111666451	PITX2	T/G	0.16	1.15 (1.10–1.21)	9.08×10−10	0.18	1.00 (0.92 −1.09)	0.95	0.18	1.14 (0.99–1.33)	0.08
rs7857118	9	22124140	CDKN2B-AS1	T/A	0.51	1.10 (1.06–1.14)	2.15×10−7	0.52	1.05 (0.99–1.12)	0.11	0.53	1.07 (0.96–1.20)	0.24
rs12627426	21	30519457	MAP3K7CL	A/T	0.16	1.13 (1.08–1.18)	2.63×10−7	0.15	1.02 (0.93–1.11)	0.70	0.15	1.20 (1.03–1.40)	0.02
rs73839819	3	72579834	RYBP	G/A	0.02	1.33 (1.19–1.48)	2.65×10−7	0.02	0.94 (0.75–1.17)	0.55	0.02	0.90 (0.60–1.36)	0.63
rs2234962	10	121429633	BAG3	T/C	0.78	1.12 (1.07–1.17)	3.55×10−7	0.79	1.00 (0.92–1.07)	0.90	0.80	1.27 (1.10–1.46)	0.001

Abbreviations: HF=heart failure; Chr=chromosome; Pos=hg19 position; RA=all-cause HF risk allele; NRA=all-cause HF non-risk allele; RAF=all-cause HF risk allele frequency; OR=odds ratio; 95% CI=95% confidence interval