Table 3.

Replication of suggestive signals from genetic association analyses for nonischemic cardiomyopathy in UK Biobank.

					UK Biobank (n cases=1,816)			BioVU Study (n cases=226)			GRADE (n cases=260)			Esslinger et al. (2017) (n cases=2,796)
Rsid	Chr	Pos	Nearest Gene	RA/ NRA	RAF	OR (95% CI)	P-value	RAF	OR (95% CI)	P-value	RAF	OR (95% CI)	P-value	RAF	OR (95% CI)	P-value
rs2234962	10	121429633	BAG3	T/C	0.78	1.30 (1.19–1.41)	2.32×10−9	0.80	1.49 (1.14–1.94)	3.12×10−3	0.79	1.39 (1.08–1.80)	0.01	0.81	1.61 (1.48–1.77)	1.70×10−25
rs2634071	4	111669220	PITX2	T/C	0.16	1.25 (1.15–1.36)	1.06×10−7	0.17	1.05 (0.82–1.35)	0.68	0.17	1.13 (0.87–1.46)	0.36	-	-	-
rs6843082*	4	111718067	PITX2	G/A	0.19	1.24 (1.14–1.34)	1.09×10−7	0.21	0.93 (0.73–1.18)	0.53	0.20	1.13 (0.89–1.43)	0.33	0.23	1.11 (1.03–1.20)	7.52×10−3
rs12138073	1	16354958	CLCNKA	T/C	0.10	1.29 (1.17–1.42)	5.35×10−7	0.10	1.06 (0.78–1.44)	0.72	0.10	1.19 (0.88–1.62)	0.26	-	-	-
rs34471231†	1	16356522	CLCNKA	G/A	0.10	1.29 (1.17–1.42)	6.58×10−7	0.10	1.05 (0.77–1.43)	0.74	0.10	1.19 (0.88–1.62)	0.26	0.10	1.20 (1.08–1.34)	9.61×10−4
rs10927875	1	16299312	ZBTB17	C/T	0.68	1.15 (1.07–1.24)	1.15×10−4	0.68	1.22 (0.98–1.50)	0.07	0.68	1.18 (0.96–1.47)	0.12	0.69	1.30 (1.21–1.40)	8.11×10−13

Abbreviations: NICM=nonischemic cardiomyopathy; Chr=chromosome; Pos=hg19 position; RA=NICM risk allele; NRA= NICM non-risk allele; RAF= NICM risk allele frequency; OR=odds ratio; 95% CI=95% confidence interval

^*rs6843082 is present in the exome chip analysis from Esslinger et al. (2017)¹⁷ and in LD with rs2634071 in the UK Biobank (r² = 0.82)

^†rs34471231 is present in the exome chip analysis from Esslinger et al. (2017)¹⁷ and in LD with rs12138073 in the UK Biobank (r² = 0.99)