Table 3.
Diagnostic accuracy of alanine aminotransferase (ALT)
| Test (IU/L) |
Sensitivity % (95% CI) |
Specificity % (95% CI) |
PPV % (95% CI) |
NPV % (95% CI) |
LR+ (95% CI) |
LR− (95% CI) |
|---|---|---|---|---|---|---|
| ALT ≥ ULN n = 62 |
79 (64–90) |
50 (36–64) |
55 (47–62) |
76 (62–85) |
1.6 (1.2–2.1) |
0.4 (0.2–0.8) |
| ALT ≥ 40 n = 25 |
44 (29–60) |
89 (78–96) |
76 (58–88) |
68 (61–73) |
4.1 (1.8–9.4) |
0.6 (0.5–0.8) |
| ALT ≥ 2× ULN n = 13 |
23 (12–39) |
95 (85–99) |
77 (49–92) |
62 (57–66) |
4.3 (1.3–14.8) |
0.8 (0.7–1.0) |
ULN = 22 IU/L for girls, 26 IU/L for boys
ALT alanine aminotransferase, ULN upper limit of normal, PPV positive predictive value, NPV negative predictive value, LR+ positive likelihood ratio, LR− negative likelihood ratio