Fig. 4.

Associations between fraction of activated regulatory T cells and interferon-inducible protein-10, indoleamine 2,3-dioxygenase and cytokine upregulation after exposure to aldrithiol-2 inactivated HIV-1 in vitro and correlation between interferon-inducible protein-10 responses in monocytes and CD4⁺ recovery after 2 and 4 years.

Correlation between percentages of activated regulatory T cells and indoleamine 2,3-dioxygenase and interferon-inducible protein-10 responses in monocytes (a) and myeloid dendritic cells (b) and cytokine responses in supernatants (c) after in-vitro stimulation with aldrithiol-2 inactivated HIV-1. (d) Associations with interferon-inducible protein-10 increase in monocytes after exposure to HIV in vitro and prospective CD4⁺ gain after 2 and 4 years. Spearman rank order correlation. The aldrithiol-2 inactivated HIV-1 responses are calculated with subtraction of the mock stimulated control. •INR, immunological nonresponder; ∘IR, immunological responder; aTregs, activated regulatory T cells (%CD147⁺⁺CD25⁺⁺ of CD4⁺); mDC, myeloid dendritic cell; MFI, median fluorescence intensity.