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. 2019 Apr 15;5(5):e447. doi: 10.1097/TXD.0000000000000890

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Copyright © 2019 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 2. — Histopathology of the explanted empty microbeads without CXCL12 (−) and with CXCL12 (+) from days 30 to 180. Samples of the microbeads at day 30 are shown in A–H. A, Tissues with embedded microbeads explanted from the NHP without CXCL12 (−). B, Fibrosis of the tissues with microbeads from the CXCL12 (−) NHP. C, Microbead sample found in the aspirate debris. D, IHC staining of the tissues from CXCL12 (−) NHP, stained with antifibroblast activation protein alpha (brown color) and with antimacrophage (red color), magnification ×10. E–G, Tissues with embedded microbeads explanted from the NHP with CXCL12 (+). H, IHC staining of the tissues from CXCL12 (+) NHP, with same staining as for the CXCL12 (−) NHP, magnification ×10. Images showing the explanted tissues (I) and free microbeads (J and K) from CXCL12 (−) NHP and explanted tissues (M) and free microbeads (N and O) from CXCL12 (+) NHP, respectively, at day 90. As it can be seen in the panels with free microbeads, there were no visible cell attachments or fibrosis present in these samples, magnification ×4 and ×20. H&E staining of the explanted tissues from CXCL12 (−) NHP with embedded microbeads at day 180 is shown in image (L) and from CXCL12 (+) NHP shown in image (P), magnification ×10. H&E, hematoxylin and eosin; IHC, immunohistochemistry; NHP, nonhuman primate.