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. 2019 Apr 15;5(5):e447. doi: 10.1097/TXD.0000000000000890

FIGURE 5.

FIGURE 5.

Cytokine and CXCL12 concentrations from the autograft microbeads study. A–C, Plasma and aspirate cytokine concentrations from the first and second NHP autografts, days 0–30. The levels of GM-CSF, IL-18, IL-5, and IL-6 increased about 1.5–2× for both autografts when compared with the baseline levels. Two-way ANOVA analysis demonstrated various significant P values for GM-CSF, IL-18, IL5, and IL-6 when comparing plasma from different time points (A and B) and aspirate for 2 NHPs (C). D and E, Plasma and aspirate concentrations of the CXCL12 in NHPs, days 0–180. D, There was a statistically significant change in the plasma CXCL12 concentrations between 2 animals for days 0, 14, and 21. E, The NHP aspirate concentrations of CXCL12 demonstrated significant change for day 30. Day 30 aspirate sample from the first NHP was assayed twice (*), and the result did not demonstrate a significant decrease in the concentration over time as compared with the blank microbeads samples. There was a much lower concentration of CXCL12 at the 180-day time point. GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; NHP, nonhuman primate.