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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2019 Apr 4;190:183–192. doi: 10.1016/j.jsbmb.2019.04.003

Figure 5: Effect of LHCGR pathway inhibition on human LHCGR promoter activity.

Figure 5:

hLGCs were cultured for 24 h in serum-free media then transfected with the 174 bp human LHCGR proximal promoter region. Cells were left untreated (C) or were treated with hCG (50 ng/ml) or forskolin (5 μM) for 48 h in the presence or absence of H89 (H), U0126 (U), MK2206 (MK) or Mithramycin A (MTM). Paired columns differ significantly from each other by t-test (P < 0.05, n = 6).