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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Neuroscience. 2019 Feb 18;406:617–625. doi: 10.1016/j.neuroscience.2019.02.012

Figure 1: Schematic of General Study Design.

Figure 1:

Four groups of mice were generated based on the factorial combination of Group (CIE vs. Air) x Stress (FSS vs. no-FSS). Mice received 4 weekly cycles of CIE or Air exposure, with each week separated by a 72-hr period (stippled boxes). Following the final CIE/Air exposure cycle, mice received FSS (10-min) (denoted by red triangles) or left undisturbed in the home-cage. Separate groups of CLT, CIE, FSS, and CIE+FSS treated mice were sacrificed 4-hr following a single FSS challenge (corresponding to 3-days post-CIE/Air exposure) or 4-hr following the 5th of 5 daily FSS sessions (corresponding to 7-days post-CIE/Air exposure) – time of sacrifice denoted by asterisk.