The diagram represents the extended family, square for male and circle for female. Individuals with MCI and dementia have been classified as symptomatic and are represented as filled icons, empty icons represent asymptomatic individuals. Individuals from whom we have information but died before the study were represented as deceased (crossed out). All 93 participants in the study were labeled with age at onset for MCI (if applicable), age at onset for Dementia (if applicable), and age at the clinical evaluation. If the age at onset was unknow the data was labeled as Not Available (NA). The symptomatic individuals from the V generation met the MCI criteria, but none of them met dementia criteria, therefore AAO for dementia was not registered.
MCI: Mild cognitive impairment, AAE: age at examination, NA: data not available
* Individual with whole genome sequencing data, + Individual used for zygosity mapping.