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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Alzheimers Dement. 2019 Feb 10;15(5):709–719. doi: 10.1016/j.jalz.2018.12.010

Figure 2.

Figure 2.

A: schematic representation of Preselenin 1 in the cell membrane. Residues that have variants known to cause Alzheimer’s disease are represented with a red border [3]. Residue 416 in TM VIII is colored in red. TM: Transmembrane

B: Color chromatogram depicting the missense variant in the PSEN1 gene.

C: Alignment of PSEN1 ortologs (uniprot.org). Residue 416 is highlighted in yellow.

* Residues that are conserved among the 5 species.

• Residues that are conserved at least in 4 species.

: Residues that are conserved at least in 3 species.