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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Curr Opin Immunol. 2019 Jan 25;57:32–39. doi: 10.1016/j.coi.2018.12.002

Figure 1. Polyreactivity in the B cell system.

Figure 1.

Schematic of the B cell development and literature-based representations of general locations of tolerance checkpoints and polyreactivity of associated B cell subsets. Shown are two B cell tolerance checkpoints. Tolerance checkpoints in the bone marrow are designated central tolerance, and those in the periphery are designated as such. Immature (imm.), transitional (trans.), mature naïve (IgM IgD), and IgA B cells (green) are indicated.