Table 2.

Multiple linear regression modeling of significant neuropathologic variables

	Brain weight		Braak tangle stage		Coexisting HpScl-TDP
	Regression estimate (95% CI)	P value	OR* (95% CI)	P value	OR* (95% CI)	P value
Unadjusted
Ethnoracial Group*
Hispanic decedents	−61 (−98, −24)	.001	2.0 (1.2, 3.4)	.005	1.8 (0.8, 3.6)	180
Black decedents	−50 (−120, 18)	.150	0.7 (0.3, 1.7)	.400	3.5 (1.0, 9.7)	.054
Adjusted for age of onset, sex, and disease duration
Ethnoracial group*
Hispanic decedents	−25 (−57, 6.3)	.120	1.3 (0.7, 2.3)	.400	1.1 (0.4, 2.4)	.900
Black decedents	−47 (−100, 9.0)	.099	0.7 (0.3, 1.6)	.340	5.4 (1.4, 17)	.016
Covariates
Age of onset	15 (7.3, 24)	.0003	0.5 (0.4, 0.6)	<.0001	2.8 (2.0, 3.8)	<.0001
Sex	−140 (−150, −130)	<.0001	1.9 (1.5, 2.5)	<.0001	0.8 (0.5, 1.2)	.3
Disease duration	−9.4 (−11, −7.7)	<.0001	1.1 (1.1, 1.1)	<.0001	1.3 (1.2, 1.3)	<.0001

Abbreviations: OR, odds ratio; 95% CI, confidence interval; HpScl, Hippocampal Sclerosis of a TDP-43 etiology.

NOTE. White decedents were inputted as the referent for the ethnoracial group.

^*All odds ratio estimates calculated by profile likelihood.