Table 5. Clinical outcomes according to different statin initiation timing.
| Variables | Time (hours) | Unadjusted HR | Adjusted HR | Propensity-score-adjusted HR | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| <24 (n=2,665) | ≥24 (n=1,256) | p value | 95% CI | p value | 95% CI | p value | 95% CI | p value | ||
| Model 1 (group I vs. II or III) | ||||||||||
| Cardiac death, MI or TVR | 381 (14.3) | 231 (18.4) | 0.001 | 0.75 (0.64–0.88) | 0.001 | 0.77 (0.66–0.91) | 0.002 | 0.78 (0.64–0.94) | 0.011 | |
| All-cause death | 356 (13.4) | 201 (16.0) | 0.027 | 0.81 (0.68–0.96) | 0.017 | 0.87 (0.73–1.08) | 0.108 | 0.87 (0.71–1.07) | 0.179 | |
| Cardiac death | 115 (4.3) | 74 (5.9) | 0.032 | 0.71 (0.53–0.95) | 0.021 | 0.79 (0.59–1.06) | 0.115 | 0.74 (0.52–1.05) | 0.090 | |
| Nonfatal spontaneous MI | 52 (2.0) | 41 (3.3) | 0.012 | 0.59 (0.39–0.89) | 0.011 | 0.60 (0.40–0.91) | 0.015 | 0.48 (0.28–0.82) | 0.007 | |
| TLR | 215 (8.1) | 121 (9.6) | 0.102 | 0.82 (0.65–1.02) | 0.074 | 0.82 (0.66–1.03) | 0.082 | 0.82 (0.63–1.07) | 0.137 | |
| TVR | 262 (9.8) | 150 (11.9) | 0.044 | 0.80 (0.66–0.98) | 0.031 | 0.81 (0.66–0.99) | 0.036 | 0.83 (0.65–1.05) | 0.122 | |
| Non-TVR | 155 (5.8) | 80 (6.4) | 0.496 | 0.90 (0.69–1.18) | 0.439 | 0.90 (0.69–1.18) | 0.456 | 0.96 (0.71–1.32) | 0.812 | |
| Stroke | 55 (2.1) | 34 (2.7) | 0.207 | 0.75 (0.49–1.15) | 0.184 | 0.76 (0.49–1.17) | 0.207 | 0.69 (0.41–1.16) | 0.164 | |
| Definite or probable stent thrombosis | 72 (2.7) | 49 (3.9) | 0.043 | 0.68 (0.47–0.98) | 0.037 | 0.69 (0.48–0.99) | 0.045 | 0.51 (0.31–0.83) | 0.006 | |
| Model 2 (group I or II vs. III) | <48 (n=3,145) | ≥48 (n=776) | ||||||||
| Cardiac death, MI or TVR | 459 (14.6) | 153 (19.7) | <0.001 | 0.72 (0.60–0.87) | 0.001 | 0.81 (0.67–0.97) | 0.022 | 0.69 (0.54–0.89) | 0.005 | |
| All-cause death | 425 (13.5) | 132 (17.0) | 0.012 | 0.78 (0.64–0.95) | 0.012 | 0.87 (0.72–1.06) | 0.173 | 0.89 (0.69–1.15) | 0.363 | |
| Cardiac death | 135 (4.3) | 54 (7.0) | 0.002 | 0.60 (0.44–0.83) | 0.002 | 0.72 (0.52–0.99) | 0.042 | 0.74 (0.49–0.98) | 0.047 | |
| Nonfatal spontaneous MI | 65 (2.1) | 28 (3.6) | 0.011 | 0.57 (0.37–0.89) | 0.014 | 0.59 (0.38–0.92) | 0.021 | 0.47 (0.24–0.91) | 0.024 | |
| TLR | 257 (8.2) | 79 (10.2) | 0.073 | 0.79 (0.61–1.02) | 0.065 | 0.79 (0.61–1.02) | 0.074 | 0.69 (0.49–0.98) | 0.039 | |
| TVR | 319 (10.1) | 93 (12.0) | 0.134 | 0.84 (0.66–1.05) | 0.127 | 0.84 (0.67–1.06) | 0.141 | 0.72 (0.52–0.98) | 0.039 | |
| Non-TVR | 180 (5.7) | 55 (7.1) | 0.152 | 0.80 (0.59–1.08) | 0.150 | 0.84 (0.67–1.06) | 0.141 | 1.05 (0.72–1.52) | 0.815 | |
| Stroke | 69 (2.2) | 20 (2.6) | 0.521 | 0.85 (0.52–1.40) | 0.531 | 0.87 (0.53–1.44) | 0.598 | 0.86 (0.45–1.65) | 0.651 | |
| Definite or probable stent thrombosis | 91 (2.9) | 30 (3.9) | 0.161 | 0.74 (0.49–1.12) | 0.159 | 0.76 (0.50–1.15) | 0.194 | 0.56 (0.31–1.02) | 0.059 | |
| Model 3 (group I vs. II) | <24 (n=2,665) | 24–48 (n=480) | ||||||||
| Cardiac death, MI or TVR | 381 (14.3) | 78 (16.3) | 0.264 | 0.84 (0.66–1.07) | 0.160 | 0.87 (0.68–1.11) | 0.268 | 0.84 (0.61–1.16) | 0.290 | |
| All-cause death | 356 (13.4) | 69 (14.4) | 0.549 | 0.90 (0.69–1.16) | 0.402 | 0.89 (0.69–1.15) | 0.368 | 0.94 (0.67–1.32) | 0.723 | |
| Cardiac death | 115 (4.3) | 20 (4.2) | 0.883 | 1.00 (0.62–1.61) | 0.997 | 0.99 (0.61–1.59) | 0.953 | 1.06 (0.57–1.95) | 0.856 | |
| Nonfatal spontaneous MI | 52 (2.0) | 13 (2.7) | 0.283 | 0.69 (0.38–1.27) | 0.237 | 0.67 (0.37–1.24) | 0.203 | 0.45 (0.17–1.19) | 0.107 | |
| TLR | 215 (8.1) | 42 (8.8) | 0.615 | 0.89 (0.64–1.24) | 0.500 | 0.94 (0.67–1.31) | 0.697 | 0.94 (0.61–1.45) | 0.775 | |
| TVR | 262 (9.8) | 57 (11.9) | 0.172 | 0.79 (0.59–1.06) | 0.116 | 0.82 (0.61–1.09) | 0.177 | 0.80 (0.55–1.18) | 0.269 | |
| Non-TVR | 155 (5.8) | 25 (5.2) | 0.598 | 1.09 (0.72–1.67) | 0.683 | 1.07 (0.70–1.64) | 0.756 | 0.99 (0.57–1.73) | 0.974 | |
| Stroke | 55 (2.1) | 14 (2.9) | 0.240 | 0.68 (0.38–1.22) | 0.196 | 0.68 (0.38–1.22) | 0.190 | 0.77 (0.35–1.70) | 0.517 | |
| Definite or probable stent thrombosis | 72 (2.7) | 19 (4.0) | 0.131 | 0.66 (0.39–1.10) | 0.108 | 0.65 (0.39–1.09) | 0.100 | 0.57 (0.27–1.20) | 0.136 | |
Propensity-score adjusted HRs were calculated in 1,248 matched pair in model 1, 767 matched pair in model 2, and 475 matched pair in model 3.
CI = confidence interval; HR = hazard ratio; MI = myocardial infarction; TLR = target-lesion revascularization; TVR = target-vessel revascularization.