Figure 3.

miR-125a-5p inhibits migration and invasion of CRC cells via directly targeting TAZ. Protein expression levels of TAZ in LoVo (A) and SW480 (B) cells transfected with miR-125a-5p mimic or mimic control were detected by Western blot. (C) Wound-healing assays were used to examine cell migration of LoVo and SW480 cells transfected with miR-NC, miR-125a-5p mimic or co-transfected with miR-125a-5p mimic and TAZ overexpression plasmids. (D) Transwell assays were used to examine cell invasion of LoVo and SW480 cells transfected with miR-NC, miR-125a-5p mimic or co-transfected with miR-125a-5p mimic and TAZ overexpression plasmids. Dates are expressed by mean ± standard deviation. **P<0.01, vs control. ^##P<0.01, ^###P<0.001 vs miR-125a-5p mimic.

Abbreviations: miR-NC, microRNA mimic control; PCDNA3-TAZ, TAZ overexpression plasmids.