Table 3.
Outcomes according to the different parameters studied
| Parameters | Series | ADT only | Cytoreduction + ADT | p |
|---|---|---|---|---|
| Average PSA nadir (ng/mL) | 66.9 | 110.7 | 16.8 | 0.025 |
| Median time to nadir (months) | 6 | 3 | 6 | 0.025 |
| Median OS (months) | 16 | 14 | 24 | 0.03 |
| Median PFS (months) | 36 | 20 | 43 | 0.025 |
| Castration resistance (number of cases) | 61 | 36 | 25 | 0.09 |
| PSA <4 ng/mL (number of cases) | 45 | 15 | 30 | 0.0001 |
| Mean PSA after progression (ng/mL) | 778.3 | 985 | 480.5 | 0.08 |
| Mean PSA after second- line treatment (ng/mL) | 807.5 | 1,052.7 | 454.4 | 0.069 |
| Median OS after progression (months) | 6 | 6 | 8 | 0.08 |
Abbreviations: OS, overall survival; PFS, progression-free survival.