Table 1.
Body weight, tissue weight, relative tissue weights, and skeletal muscle citrate synthase activity of SED and ET Copenhagen rats, and SED, ET, SED-TB and ET-TB Nude rats
| Animal Characteristics | Copenhagen rats | Nude rats | |||||||
|---|---|---|---|---|---|---|---|---|---|
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|
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| SED (n = 10) | ET (n = 10) | p-value | SED (n = 4) | ET (n = 6) | p-value | SED-TB (n = 4) | ET-TB (n = 4) | p-value | |
| Body weight (BW) (g) | 340.7 ± 7.1 | 333.8 ± 10.4 | 0.59 | 403.8 ± 12.6 | 373.0 ± 13.9 | 0.16 | 403.3 ± 20.0 | 379.8 ± 19.5 | 0.43 |
| Prostate weight (PW) (g) | 0.56 ± 0.03 | 0.58 ± 0.04 | 0.70 | 0.69 ± 0.09 | 0.72 ± 0.05 | 0.79 | 0.41 ± 0.04 | 0.69 ± 0.13 | 0.09 |
| PW/BW (%) | 0.17 ± 0.01 | 0.17 ± 0.01 | 0.51 | 0.17 ± 0.02 | 0.19 ± 0.02 | 0.44 | 0.10 ± 0.00 | 0.18 ± 0.04 | 0.07 |
| Heart weight/BW (%) | 0.24 ± 0.00 | 0.27 ± 0.01 | 0.0017* | 0.28 ± 0.00 | 0.29 ± 0.01 | 0.67 | 0.27 ± 0.01 | 0.30 ± 0.01 | 0.28 |
| Tumor weight (g) | - | - | - | - | - | - | 0.26 ± 0.12 | 0.26 ± 0.10 | 0.97 |
| Skeletal Muscle Citrate Synthase Activity (µmol/min/g) | |||||||||
| Soleus | 27.5 ± 0.7 | 38.6 ± 2.2 | < 0.0001** | 9.86 ± 0.55 | 13.91 ± 1.83 | 0.12 | 10.01 ± 0.20 | 14.54 ± 1.55 | 0.02* |
| Red gastrocnemius | 42.8 ± 2.2 | 50.9 ± 2.2 | 0.02* | 9.04 ± 0.30 | 10.93 ± 1.00 | 0.02* | 8.68 ± 0.83 | 11.07 ± 1.43 | 0.73 |
Values are expressed as mean ± SEM. n, number of rats; SED, sedentary (control); ET, exercise-trained; SED-TB, sedentary tumor-bearing; ET-TB, exercise-trained tumor-bearing.
*
P ≤ 0.05 vs. SED or SED-TB;
**
P ≤ 0.0001 vs. SED.