Table 1.

Changes of NAD levels in metabolic tissues with obesity or aging

Model	Tissue	Change	Description	Confirmatiom	References
Obesity	Liver	↓	C57BL/6 congenic mice fed a HFD for 6–8 months	HPLC	[8]
		↓	BALB/c mice fed a HFD for 16–20 weeks	Enzymatic	[96]
		↓	C57BL/6 J mice fed a HFD for 12 weeks	LC/MS	[9]
		↓	C57BL/6 J mice fed a HFHSD for 9 or 18 weeks	LC/MS	[10]
		→	C57BL/6JBomTac mice fed a HFD for 6–48 weeks	LC/MS	[11]
	Skeletal muscle	↓	C57BL/6 mice fed a HFD for 6–8 months	HPLC	[8]
		↓	C57BL/6 mice fed a HFD from 3 to 9 months	HPLC	[12]
		↓	C57BL/6 mice fed a HFD from 6 to 16 weeks	LC/MS	[13]
	Adipose tissue	↓	C57BL/6 mice fed a HFD for 6–8 months	HPLC	[8]
		↓	C57BL/6 congenic mice fed a HFD from 6 to 16 weeks	Enzymatic	[14]
	Hypothalamus	↓	C57BL/6 mice fed a HFHSD for 4 weeks	LC/MS	[15]
		↓	db/db mice at 8 months of age	LC/MS	[15]
Aging	Liver	→	C57BL/6 mice (25–31 months old v.s. 3–6 months old)	HPLC	[8]
		↓	C57BL/6 J mice (24 months old v.s. 6 months old)	HPLC	[16]
		↓	Human (> 60 years old v.s. < 45 years old)	Enzymatic	[17]
		↓	Male C57BL/6 J mice (20 months old v.s. 4 months old)	Enzymatic	[17]
		↓	Male C57BL/6 mice (32 months old v.s. 5 months old)	LC/MS	[18]
		↓	Male C57BL/6 N mice (24 months old v.s. 3 months old)	LC/MS	[19]
	Skeletal muscle	↓	C57BL/6 mice (25–31 months old v.s. 3–6 months old)	HPLC	[8]
		↓	C57BL/6 J mice (22 months old v.s. 6 months old)	Enzymatic	[20]
		↓	C57BL/6 J mice (24 months old v.s. 6 months old)	HPLC	[16]
		↓	Male C57BL/6 mice (32 months old v.s. 5 months old)	Enzymatic	[18]
		↓	C57BL/6 mice (24 months old v.s. 4 months old)	HPLC	[21]
		↓	C57BL/6 J mice (22–24 months old v.s. 1 months old)	Enzymatic	[22]
		↓	Male C57BL/6 N mice (24 months old v.s. 3 months old)	LC/MS	[19]
	Adipose tissue	↓	C57BL/6 mice (25–31 months old v.s. 3–6 months old)	HPLC	[8]
		↓	Male C57BL/6 mice (32 months old v.s. 5 months old)	Enzymatic	[18]

HPLC High Performance Liquid Chromatography, LC/MS Liquid Chromatography-Mass spectrometry