Table 1. Comparison of different parameters investigated.
| Parameters | Noble 13-week | Noble 18-week | Wistar 18-week | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Placebo | T+E2 | P | Placebo | T+E2 | P | Placebo | T+E2 | P | |||
| Body weight change (g) | 60.8 ±7.2 | −35.2±4.5 | <0.0001 (T) | 67.7±6.5 | −36.6±6.3 | <0.0001 (T) | 143.0±6.9 | −29.6±3.2 | <0.0001 (T) | ||
| Pituitary weight (absolute values) (10−2 g) | 1.1±0.04 | 3.2±0.3 | <0.0001 (T) | 1.1±0.05 | 5.1±0.3 | <0.0001 (T) | 1.2±0.06 | 4.8±0.8 | 0.0002 (T) | ||
| Prostate weight (absolute values) (10−1 g) | 11.1±0.4 | 19.9±0.5 | <0.0001 (T) | 12.0±0.7 | 19.7±0.4 | <0.0001 (T) | 14.1±0.9 | 24.9±1.2 | <0.0001 (T) | ||
| Bladder weight (absolute values) (10−1 g) | 1.4 ±0.05 | 2.0±0.06 | <0.0001 (T) | 1.5±0.04 | 2.1±0.1 | 0.0073 (T) | 1.3±0.04 | 1.4±0.1 | NS (T) | ||
| Number of Inflamed prostate acini | 0 | 15±2.4 | 0 | 32±6.4 | 0 | 18±3.8 | |||||
| Cancer incidence (% of total) | 0 | 100 | 0 | 100 | 0 | 57 | |||||
| Urodynamical parameters | |||||||||||
| Basal bladder pressure (cmH2O) | 4.4±0.9 | 4.4±1.1 | NS (M) | NM | NM | 6.2±0.8 | 15.9±2.2 | 0.0013 (T) | |||
| Max bladder pressure (cmH2O) | 59.0±2.1 | 60.4±2.3 | NS (T) | NM | NM | 42.3±1.4 | 55.5±2.5 | 0.0006 (T) | |||
| Mean bladder pressure (cmH2O) | 42.0±1.9 | 44.2±1.1 | NS (T) | NM | NM | 32.5±1.9 | 46.0±2.4 | 0.004 (M) | |||
| Max. flow rate (mL/min) | 32.5±8.6 | 17.9±4.4 | NS (T) | NM | NM | 23.2±7.3 | 16.5±4.3 | NS (T) | |||
| Mean flow rate (mL/min) | 5.0±1.2 | 3.5±0.7 | NS (T) | NM | NM | 4.4±1.3 | 2.7±0.5 | NS (T) | |||
| Micturition time (s) | 8.7±1.3 | 12.0±1.9 | NS (M) | NM | NM | 13.4±3.4 | 25.0±3.0 | 0.038 (M) | |||
| Micturition interval (min) | 1.9±0.3 | 2.5±0.4 | NS (T) | NM | NM | 2.2±0.3 | 2.8±0.2 | NS (T) | |||
| Bladder capacity (mL) | 0.7±0.07 | 1.0±0.10 | 0.012 (T) | NM | NM | 0.8±0.07 | 1.4±0.26 | 0.029 (M) | |||
| Residual urine volume (mL) | 0.32±0.06 | 0.58±0.09 | 0.030 (T) | NM | NM | 0.48±0.06 | 1.08±0.29 | 0.053 (M) | |||
Upper values in the rows are mean and SEM values for each parameter. Lower values in each row are P values from pairwise comparisons against each placebo-groups. NS, not significantly different. P values >0.05 but <0.1 are shown also as exact values. Statistical analysis between each T+E2-group compared to their placebo-groups was performed either with t-test (T) or Mann-Whitney test (M). NM, not measured. Animal and organ weights and urodynamical parameters: Wistar groups n=7; Noble groups n=10; histological parameters: Noble 13-week group n=8, Noble 18-week group n=5, Wistar 18-week group n=7.