Figure 2.

Behavioral experiments in the established mouse model. A. Times through the central grille of the Open-field test (OFT). B. Total distance traveled in the OFT. C. Middle dist/Total dist of the OFT. Middle dist = smldist/lardist, Total dist = smldist + lardist. Lardist denoted the total distance (in cm) covered by the animal in large movements. Smldist denoted the total distance covered by the animal in small movement. D. Freezing behavior test. The percentage of freezing behavior was the time spent in freezing behavior/the total time during each measurement period. E and F. Elevated plus maze test. “Percent of open arms entries” denoted the numbers of entries into the open arms/(the numbers of entries into the open arms + closed arms); “Percent of time spent in open arms” indicated the time spent in the open arms/(the time spent in the open arms + closed arms). Data were presented as mean ± SEM through ANOVA. Groups were compared by conducting Bonferroni’s test, n = 8. ^*P < 0.05, ^***P < 0.001 vs. the sham group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. the PTSD group; ^sP < 0.05, ^ssP < 0.01, ^sssP < 0.001 vs. the PTSD+K group.