Figure 2.

Effects of Cyp1b1 and HFD diet on spatial learning and memory detected by Morris Water Maze. A. The escape latency (mean ± S.E.M) to find the platform was higher both in female WT and KO mice fed HFD. The learning curves indicated that KO mice learned the task faster when comparing with WT mice. B. Probe trial data showed that all groups spent significant longer time in the target quadrant than time spent in quadrants 1 and 2. KO mice performed better in the target area compared to WT controls either fed HFD or NC. C. Typical swimming paths in the probe trial. Compared with WT mice, KO mice found the platform more quickly and efficiently. D. Representative image of forced swimming test. ^*Significantly different from WT-NC, ^#Significantly different from WT-HFD, P<0.05.