Figure 6.

Up-regulation of Nuclear factor-erythroid-2-related factor 2 (Nrf2) protein and its target genes in the face of oxidative stress induced by HFD. A. Cyp1b1 deletion promoted Nrf2 mRNA expression. B. Representative Western blots of Nrf2, and quantified data showed that Cyp1b1 deletion sustained Nrf2 expression suppressed by HFD. C. Nrf2 target genes, heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase (quinone) (NQO-1) were elevated by Cyp1b1 deletion in both NC and HFD groups. ^*Significantly different from WT-NC, ^#Significantly different from WT-HFD, P<0.05.