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Hypoxia substantially activated the Smad pathway. A. LY2109761 significantly inhibited the Smad pathway under normoxic and hypoxic conditions. B. Hypoxia inhibited the protein expression of E-cadherin in HepG2 cells, while LY2109761 enhanced E-cadherin expression under normoxic and hypoxic conditions. *P<0.05, **P<0.01 versus the control (in normal groups), ##P<0.01 versus the control (in hypoxic groups).
