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Exenatide ameliorated advanced glycation end products (AGEs)-induced activation of p38 in human primary chondrocytes. Human primary chondrocytes were stimulated with 100 μg/ml AGEs in the presence or absence of exendin-4 (a form of exenatide) at the concentrations of 10 and 20 nM for 2 h. Phosphorylated and total levels of p38 was determined by western blot analysis (a, b, c, P < 0.01 vs. previous column group).
