Table 2.

Outcome parameters in the initiation phase of warfarin therapy according to genotypes

	n	INR1-0/dose	INR2-1/dose	INR3-2/dose	INR4-3/dose	INR5-4/dose	INR6-5/dose
VKORC1
AA	236	0.048 (0.024-0.097)	0.044 (0.020-0.088)	0.040 (0.020-0.088)	0.052 (0.020-0.102)	0.052 (0.012-0.104)	0.044 (0.008-0.092)
GA	47	0.044 (0.024-0.072)	0.020 (0.000-0.048)	0.016 (-0.004-0.046)	0.022 (0.001-0.048)	0.028 (0.002-0.050)	0.012 (-0.004-0.044)
GG	4	0.036 (0.024-0.060)	0.032 (0.010-0.044)	0.028 (0.002-0.048)	0.010 (-0.005-0.022)	0.008 (-0.007-0.014)	0.006 (0.004-0.014)
P-value		0.443	0.000	0.000	0.000	0.000	0.000
CYP2C9
*1*1	268	0.044 (0.020-0.088)	0.040 (0.016-0.078)	0.036 (0.014-0.076)	0.044 (0.016-0.088)	0.044 (0.008-0.088)	0.036 (0.000-0.076)
*1*3	18	0.048 (0.028-0.108)	0.044 (0.012-0.108)	0.044 (0.012-0.120	0.096 (0.026-0.206)	0.080 (0.008-0.194)	0.072 (0.005-0.196)
*3*3	1	0.020	0.012	-0.028	0.048	0.144	0.144
P-value*		0.347	0.612	0.235	0.003	0.015	0.011
ORM1
*F*F	184	0.044 (0.020-0.084)	0.040 (0.012-0.084)	0.036 (0.012-0.080)	0.044 (0.0150.088)	0.044 (0.008-0.092)	0.032 (0.000-0.076)
*F*S	92	0.044 (0.017-0.092)	0.036 (0.014-0.072)	0.036 (0.012-0.073)	0.048 (0.016-0.103)	0.052 (0.012-0.108)	0.048 (0.008-0.092)
*S*S	11	0.052 (0.028-0.130)	0.040 (0.024-0.106)	0.040 (0.024-0.068)	0.048 (0.020-0.116)	0.032 (-0.002-0.060)	0.012 (-0.021-0.055)
P-value		0.215	0.477	0.444	0.610	0.015	0.005
CYP4F2
CC	217	0.052 (0.024-0.092)	0.040 (0.016-0.084)	0.040 (0.012-0.080)	0.048 (0.016-0.092)	0.044 (0.008-0.092)	0.036 (0.000-0.076)
CT	68	0.030 (0.010-0.074)	0.032 (0.013-0.061)	0.036 (0.016-0.068)	0.041 (0.016-0.092)	0.050 (0.012-0.100)	0.040 (0.004-0.092)
TT	2	0.065 (0.042-0.083)	0.052 (0.021-0.105)	0.028 (0.023-0.070)	0.044 (0.012-0.207)	0.010 (-0.010-0.080)	0.041 (-0.026-0.034)
P-value		0.000	0.208	0.825	0.858	0.182	0.119
Sex
Male	107	0.040 (0.017-0.076)	0.040 (0.016-0.076)	0.036 (0.012-0.068)	0.044 (0.015-0.081)	0.042 (0.003-0.096)	0.028 (0.000-0.076)
Female	180	0.048 (0.024-0.092)	0.040 (0.016-0.088)	0.038 (0.013-0.088)	0.048 (0.016-0.099)	0.048 (0.012-0.096)	0.040 (0.004-0.084)
P-value		0.068	0.590	0.349	0.268	0.405	0.145
Total	287	0.044 (0.020-0.088)	0.040 (0.016-0.080)	0.036 (0.012-0.076)	0.044 (0.016-0.092)	0.048 (0.008-0.096)	0.038 (0.000-0.080)

Values are given as median (inter-quartile range);

^*compared with *1*1 and *1*3.