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. 2019 May 2;13:383. doi: 10.3389/fnins.2019.00383

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Copyright © 2019 Orenbuch, Fortis, Taesuwan, Yaffe, Caudill and Golan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASD-like behavior – proportion of symptomatic male (A) and female (B) mice among experimental groups. C1 metabolism levels categorized by phenotype (Male + Female) in the cerebral cortex for methionine (C) and betaine (D) and in the basal forebrain for methionine (E) and for betaine/choline ratio (F). N = Wt-Wt-CD, 28; Non-Symptomatic, 78; Symptomatic, 21. (A,B) Wt-Wt-CD (W-W); Wt-Het-CD (W-H); Het-Het-CD (H-H); Het-Het-PP (H-H-PP); Het-Het-PN (H-H-PN). N, as detailed in Table 1. Because the small group size of male Het-Het-PN (group 5, n = 3) precluded statistical analysis and extraction of the percent of symptomatic mice, the data for these mice were excluded from the figures. Data are presented as means ± SEM. P-value refers to the difference compared to Wt-Wt-CD group.