Table 1.
Percent of symptomatic mice, Classes 1 and 2.
| Sex | Male |
Female |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 5 | |||
| Genotype | Maternal | MTHFR+/+ | MTHFR+/- | MTHFR+/- | MTHFR+/- | MTHFR+/+ | MTHFR+/- | MTHFR+/- | MTHFR+/- | MTHFR+/- | ||
| Offspring | MTHFR+/+ | MTHFR+/+ | MTHFR+/- | MTHFR+/- | MTHFR+/+ | MTHFR+/+ | MTHFR+/- | MTHFR+/- | MTHFR+/- | |||
| Diet | CD | CD | CD | PP | All | CD | CD | CD | PP | PN | All | |
| Number of mice | All | 12 | 13 | 10 | 11 | 46 | 13 | 8 | 12 | 8 | 7 | 49 |
| ASD-class 1 | 0 | 7 | 4 | 2 | 13 | o | 5 | 6 | 1 | 1 | 13 | |
| ASD-class 2 | 0 | 6 | 2 | 0 | 8 | 0 | 3 | 1 | 0 | 0 | 4 | |
| non Symptomatic | 12 | 6 | 6 | 9 | 33 | 13 | 4 | 6 | 7 | 7 | 37 | |
| % of mice Symptomatic | ASD-class 1 | 0 | 54 | 40 | 18 | 0 | 56 | 50 | 13 | 14 | ||
| ASD-class 2 | 0 | 46 | 20 | 0 | 0 | 33 | 8 | 0 | 0 | |||
| non Symptomatic | 100 | 46 | 60 | 82 | 100 | 44 | 50 | 55 | 86 | |||
| χ2 vs. Wt-Wt-CD | 4.40E-36 | 1.50E-09 | 4.15E-35 | 2.99E-24 | ||||||||
| χ2 vs. Het-Het-CD | 2.20E-09 | 9.40E-15 | 1.30E-13 | |||||||||
Number and percent of non-symptomatic, symptomatic-class 1 and symptomatic-class 2 mice among the experimental groups. Because the small group size of male Het-Het-PN (group 5, n = 3) precluded statistical analysis and extraction of the percent of symptomatic mice, the data for these mice were excluded from the table. ASD-Class 1, repetitive; ASD-class 2, repetitive + social deficit, Chi Square test with post hoc Holm–Bonferroni correction.