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. 2019 Mar 27;47(9):4707–4720. doi: 10.1093/nar/gkz208

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Published by Oxford University Press on behalf of Nucleic Acids Research 2019.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 7. — Engineered EcRNase III cleaves in vitro transcribed dsRNA into a heterogeneous mixture of siRNAs with a narrow size distribution centered at 22 nt. (A) The percentage of 22-nt products to the total number of reads was plotted for EcRNase III and its single mutants. (B) The percentage of 22-nt products to the total number of reads was plotted for EcRNase III and its double and triple mutants. (C) No consensus sequence of 22-nt cleavage products were detected in the triple mutant (EEQ) of EcRNase III.