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. 2019 Mar 13;47(9):4778–4797. doi: 10.1093/nar/gkz168

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Tubercidin impairs mRNA export of endogenous and exogenous β-actin mRNAs and histone non-polyadenylated mRNAs. (A) Dox-induced β-actin mRNAs were detected in U2OS cells after tubercidin treatment for 6 h and (B) endogenous β-actin mRNAs were detected in MEFs after tubercidin treatment for 3 h using RNA FISH with a probe to the MS2 region in the 3′UTR of the mRNAs (yellow). Big yellow dot in A and strong dots in B are transcription sites. Hoechst DNA stain is in blue. Boxed regions are shown in the merge. Bar = 5 μm. (C) Histone H2B mRNAs were detected in U2OS cells after tubercidin treatment for 6 h using RNA FISH with a probe to the coding region (yellow). Hoechst DNA stain is in blue. Bar = 5 μm.