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. 2019 Apr 19;62(9):4483–4499. doi: 10.1021/acs.jmedchem.9b00020

Figure 7.

Figure 7

Preliminary pharmacokinetics of compound 18. (a) Oral PK study conducted at 10 mg·kg–1 utilizing 9 Swiss Webster Female mice with three animal bleeds per time point. Maximum plasma concentration of 0.13 ± 0.02 μg·mL–1 observed at 4 h following gavage. The AUC0–24h of 1.8 μg·h·mL–1 was calculated using the linear trapezoid rule method. (b) Snapshot PK studies conducted from plasma samples taken from tolerability mice at 50, 100, and 200 mg·kg–1 following first initial dose. 10 mg·kg–1 data included for comparison. (c) Cmax, tmax, and AUC of compound 18 at four dose levels.