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. 2019 Feb 13;10(5):708–713. doi: 10.1021/acsmedchemlett.9b00002

Figure 1.

Figure 1

(A) Chemical structure of the phosphinic pseudopeptide DG046. (B) DG046 bound in the ERAP1 active site. The inhibitor is shown in yellow sticks and the main residues in ERAP1 that make interactions are shown in green. Oxygen atoms are in red, nitrogen in blue, phosphorus in orange. The active site zinc(II) is shown as a gray sphere. 2Fo-Fc electron density map is shown in blue mesh (contour level 2.0 sigma). The approximate location of the active site specificity pockets S1, S1′, and S2′ are indicated.