Table 3. Association with rs2476601 for drugs with at least 3 case carriers in the European cohort and OR > 1.
Drug results are ordered by p-value
| DRUGS | # Cases | AF | OR | 95%CI | P |
|---|---|---|---|---|---|
| Amoxacillin/Clavulanic Acid | 444 | 0.13 | 1.62 | 1.32–1.98 | 0.000004 |
| Terbinafine | 15 | 0.20 | 3.23 | 1.29–8.1 | 0.01 |
| Sulfamethoxazole/Trimethoprim | 42 | 0.17 | 2.07 | 1.16–3.71 | 0.01 |
| Methotrexate | 9 | 0.22 | 3.34 | 1.09–10.16 | 0.03 |
| Rofecoxib | 6 | 0.25 | 4.08 | 1.05–15.82 | 0.04 |
| Valproic Acid | 16 | 0.18 | 2.43 | 0.99–5.95 | 0.05 |
| Flupirtin | 6 | 0.25 | 4.43 | 0.98–20.05 | 0.05 |
| Fenofibrate | 10 | 0.20 | 2.93 | 0.97–8.87 | 0.06 |
| Erythromycin | 11 | 0.18 | 2.89 | 0.95–8.78 | 0.06 |
| Doxycycline | 6 | 0.25 | 3.21 | 0.85–12.1 | 0.09 |
| Pravastatin | 6 | 0.25 | 3.21 | 0.83–12.47 | 0.09 |
| Nimesulide | 20 | 0.12 | 2.10 | 0.81–5.41 | 0.12 |
| Cefuroxime | 4 | 0.25 | 3.45 | 0.69–17.28 | 0.13 |
| Ethinylestradiol/Levonorgestrel | 7 | 0.21 | 2.53 | 0.71–9.05 | 0.15 |
| Isoniazid | 43 | 0.13 | 1.59 | 0.84–3.02 | 0.16 |
| Celecoxib | 9 | 0.17 | 2.37 | 0.69–8.19 | 0.17 |
| Flucloxacillin | 195 | 0.11 | 1.24 | 0.90–1.71 | 0.18 |
| Nitrofurantoin | 74 | 0.12 | 1.40 | 0.85–2.32 | 0.19 |
| Piroxicam | 5 | 0.20 | 2.85 | 0.60–13.68 | 0.19 |
| Gabapentin | 5 | 0.20 | 2.79 | 0.58–13.39 | 0.2 |
| Cefazolin | 21 | 0.14 | 1.59 | 0.67–3.8 | 0.3 |
| Mercaptopurine | 10 | 0.15 | 1.72 | 0.50–5.97 | 0.39 |
| Imatinib | 8 | 0.12 | 1.70 | 0.38–7.56 | 0.49 |
| Ticlopidine | 5 | 0.10 | 2.01 | 0.24–16.73 | 0.52 |
| Atorvastatin | 29 | 0.10 | 1.32 | 0.56–3.09 | 0.53 |
| Minocycline | 32 | 0.11 | 1.29 | 0.58–2.86 | 0.53 |
| Interferon Beta-1a | 4 | 0.12 | 1.90 | 0.21–16.79 | 0.57 |
| Amiodarone | 5 | 0.20 | 1.64 | 0.28–9.73 | 0.59 |
| Diclofenac | 66 | 0.10 | 1.17 | 0.67–2.04 | 0.59 |
| Ibuprofen | 15 | 0.10 | 1.36 | 0.41–4.52 | 0.62 |
| Herbal and dietary products | 58 | 0.10 | 1.19 | 0.65–2.17 | 0.58 |
| Disulfiram | 8 | 0.12 | 1.40 | 0.32–6.13 | 0.65 |
| All Other Therapeutic Products | 9 | 0.11 | 1.33 | 0.30–5.93 | 0.71 |
| Nicotinic Acid | 4 | 0.12 | 1.45 | 0.17–12.17 | 0.73 |
| Lisinopril | 5 | 0.10 | 1.45 | 0.17–12.17 | 0.74 |
| Phenytoin | 10 | 0.10 | 1.18 | 0.27–5.11 | 0.82 |
| Rosuvastatin | 4 | 0.12 | 1.27 | 0.14–11.29 | 0.83 |
| Sertraline | 6 | 0.08 | 1.17 | 0.15–9.27 | 0.88 |
| Levofloxacin | 17 | 0.09 | 1.05 | 0.32–3.44 | 0.94 |
#
Cases= number of cases for each drug
AF = Allele frequcncy; OR = Odd Ratio; ULC= 95% lower Confidence interval of the Odds Ratio; ULC= 95% upper Confidence Interval of the Odds Ratio; P = logistic p-value. In bold drugs previously known to be associated with at least one HLA risk allele.