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. 2019 Apr 12;10(5):767–772. doi: 10.1021/acsmedchemlett.9b00025

Scheme 1. Synthesis of PROTACs 6a6j.

Scheme 1

Reagents and conditions: (a) 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo [4,5-b]-pyridinium 3-oxide hexafluorophosphate (HATU), N,N-diisopropylethylamine (DIPEA), N,N-dimethylformamide (DMF), room temperature (rt), 39–71%; (b) trifluoroacetic acid (TFA), dichloromethane (DCM), rt.