Figure 3.

Effects of LMAE on superoxide and nitric oxide production ex vivo. LMAE (50 mg/kg) was administered daily by oral gavage for 3 weeks, and osmotic minipumps delivering NaCl (0.9%) or angiotensin II (0.5 mg/kg/day) were implanted 1 week after the start of the LMAE pretreatment. Nitric oxide (NO^·) (a) and superoxide (O₂ ⁻) (b) production was measured in femoral arteries. NaCl: mice treated with NaCl, control; NaCl+LMAE: mice treated with LMAE and NaCl; Ang II: mice treated with Ang II; Ang II+LMAE: mice treated with LMAE and Ang II. NaCl and Ang II groups were treated with an equal volume of vehicle (2% of Tween 80). The results are expressed as mean ± SEM. n = 7-8/group; ^∗ p < 0.05.