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. 2019 Apr 28;2019:3658215. doi: 10.1155/2019/3658215

Figure 3.

Figure 3

Correlation of B-cell factors and immunoglobulins in RA patients. (a) Spearman correlation matrix of soluble B-cell factors and Ig levels in RA. (b-d) Scatter plots demonstrating individual correlations between sBCMA and IgA (b), IgG (c), and IgM (d). Serum sBCMA (but not CD40, CD40L, or APRIL) had a positive correlation with serum IgG (rho = 0.6, p < 0.01) and IgA (rho = 0.6, p < 0.001), both ASC-derived class-switched antibodies, but not with IgM levels which is produced without class-switching. Moderate correlations were also seen between B-cell activation factors (CD40, CD40L) and sBCMA levels. ∗ p < 0.05, ∗∗ p < 0.01, and∗∗∗ p < 0.001.