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. 2019 Apr 29;8(9):e010917. doi: 10.1161/JAHA.118.010917

Figure 6.

Figure 6

Contractile response of uterine arteries from wild‐type (WT), Rgs2−/−, and Rgs5−/− mice to phenylephrine (PE) in the absence (A through F) or presence (G through L) of Nω‐Nitro‐l‐arginine methyl ester (L‐NAME) at nonpregnant (NP), gestation day 15 (D15), and postpartum day 3 (PPD3). A and G, Contractile responses of WT, Rgs2−/−, and Rgs5−/− uterine arteries to PE at NP period (WT n=3, Rgs2−/− n=3, and Rgs5−/− n=4 mice). B and H, Contractile responses of WT, Rgs2−/−, and Rgs5−/− uterine arteries to PE at D15 (WT n=5, Rgs2−/− n=5, and Rgs5−/− n=4 mice). C and I, Contractile responses of WT, Rgs2−/−, and Rgs5−/− uterine arteries to PE at PPD3 (WT n=4, Rgs2−/− n=3, and Rgs5−/− n=4 mice). D and J, Contractile responses of WT uterine arteries at NP, D15, and PPD3 to PE (NP n=4, D15 n=4, and PPD3 n=4 mice). E and K, Contractile responses of Rgs2−/− uterine arteries at NP, D15, and PPD3 uterine arteries to PE (NP n=3, D15 n=5, and PPD3 n=3 mice). F and L, Contractile responses of Rgs5−/− uterine arteries at NP, D15, and PPD3 to PE (NP n=3, D15 n=5, and PPD3 n=4 mice). Values are expressed as mean±SE of percent decreases in vessel lumen diameter. *P<0.05 WT vs Rgs2−/−; # P<0.05 WT vs Rgs5−/−; +,++ P<0.05, 0.01 Rgs2−/− vs Rgs5−/−; $,$$ P<0.05, 0.01 D15 vs PPD3; & P<0.05 NP vs PPD3.