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. 2019 Apr 29;8(9):e010917. doi: 10.1161/JAHA.118.010917

Figure 10.

Figure 10

Vasodilatory response of uterine arteries from wild‐type (WT), Rgs2−/−, and Rgs5−/− mice to acetylcholine (ACh) in the absence (A through F) or presence (G through L) of Nω‐Nitro‐L‐arginine methyl ester (L‐NAME) at nonpregnant (NP), gestation day 15 (D15), and postpartum day 3 (PPD3). All the vessels were preconstricted with 10 μmol/L of phenylephrine before the application of increasing concentrations of ACh. A and G, Vasodilatory responses of WT, Rgs2−/−, and Rgs5−/− uterine arteries to ACh at NP period (WT n=4, Rgs2−/− n=3, and Rgs5−/− n=3 mice). B and H, Vasodilatory responses of WT, Rgs2−/−, and Rgs5−/− uterine arteries to ACh at D15 (WT n=3, Rgs2−/− n=3, and Rgs5−/− n=4 mice). C and I, Vasodilatory responses of WT, Rgs2−/−, and Rgs5−/− uterine arteries to ACh at PPD3 (WT n=5, Rgs2−/− n=3, and Rgs5−/− n=4 mice). D and J, Vasodilatory responses of WT uterine arteries at NP, D15, and PPD3 to ACh (NP n=3, D15 n=5, and PPD3 n=4 mice). E and K, Vasodilatory responses of Rgs2−/− uterine arteries at NP, D15, and PPD3 uterine arteries to ACh (NP n=4, D15 n=3, and PPD3 n=3 mice). F and L, Vasodilatory responses of Rgs5−/− uterine arteries at NP, D15, and PPD3 to ACh (NP n=3, D15 n=4, and PPD3 n=4 mice). Values are expressed as mean±SE of percent increases in vessel lumen diameter. Data were analyzed using the nonparametric Mann–Whitney U test. *P<0.05 WT vs Rgs2−/−; # P<0.05 WT vs Rgs5−/−; & P<0.05 Rgs2−/− vs Rgs5−/−; ^ P<0.05 NP vs D15; $ P<0.05 NP vs PPD3; + P<0.05 D15 vs PPD3.