Figure 2. Assessment of 98 Systematic Reviews of Interventions for the Management of Corneal Diseases.

^aReasons for nonapplicability of certain systematic reviews for certain criteria are as follows: For criteria 6, 8, 9, 10, and 13, three systematic reviews did not include any studies. For criterion 7, three systematic reviews did not include any studies, and 13 systematic reviews included studies but did not assess risk of bias in included studies (thus classified as unreliable). For criterion 11, three systematic reviews did not include any studies, and 2 systematic reviews included only 1 study each. For criterion 12, three systematic reviews did not include any studies, 2 systematic reviews included only 1 study each, and 35 systematic reviews included more than 1 study but did not conduct a quantitative synthesis.

^bThe 5 criteria used for assessing the reliability of systematic reviews are 1, 3, 6, 12, and 15.