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. Author manuscript; available in PMC: 2020 Mar 20.
Published in final edited form as: ACS Chem Neurosci. 2018 Dec 14;10(3):1679–1695. doi: 10.1021/acschemneuro.8b00600

Figure 2.

Figure 2

SW-100 is a highly potent and selective HDAC6 inhibitor. (a) Structures of compounds 6–12, and SW-100. (b) Heat map summary of HDAC activities. (c) Full HDAC potency table of 6–12, SW-100, TubA, and NexA. IC50 values are the mean of two experiments ± SD obtained from curve-fitting of a 10-point enzymatic assay starting from 30 μM with 3-fold serial dilution against all HDAC isoform; TSA was tested in singlet 10-dose IC50 mode with 3-fold serial dilution starting at a concentration of 10 μM against HDAC class I, IIb, and IV isoforms; TMP269, a selective HDAC class IIa inhibitor, was tested in singlet 10-dose IC50 mode with 3-fold serial dilution starting at a concentration of 10 μM against HDAC class IIa isoforms.