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SW-100 selectively inhibits HDAC6-CD2 and enhances α-tubulin acetylation in cells. (a–d) HDAC1/6 NanoBRET target engagement assay for compound SW-100 in HEK293. IC50 values are the mean of four experiments ± SEM obtained from curve-fitting of a 12-point engagement assay starting from a concentration of 20 μM with 3-fold serial dilution. SAHA was used as a positive control.
