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. Author manuscript; available in PMC: 2020 Mar 20.
Published in final edited form as: ACS Chem Neurosci. 2018 Dec 14;10(3):1679–1695. doi: 10.1021/acschemneuro.8b00600

Figure 6.

Figure 6

SW-100 effects on performance of Fmr1−/− mice in four cognitive tasks. (a) Performance of WT mice (n = 17) and Fmr1−/− mice (n = 18) in the coordinate spatial processing task (means ± SEM; *p < 0.05 compared to vehicle-treated WT mice). (b) Performance of WT mice (n = 17) and Fmr1−/− mice (n = 18) in the categorical spatial processing task (means ± SEM; *p < 0.05 compared to vehicle-treated WT mice). (c, d) Performance of WT mice (n = 18) and Fmr1−/− mice (n = 16) in novel object recognition. (c) Percent time spent exploring the novel (N) and familiar (F) object (means ± SEM; *p < 0.01 compared to time spent with familiar object). (d) Discrimination index (means ± SEM; *p < 0.01 compared to vehicle-treated WT mice). (e, f) Performance of WT mice (n = 17) and Fmr1−/− mice (n = 18) on the temporal order task. (e) Percent time spent exploring the first (1) and last (3) object presented. (means ± SEM; *p < 0.05 compared to time spent with object 1); (f) Discrimination index (means ± SEM; *p < 0.05 compared to vehicle-treated WT). (g) Scheme of treatment and testing. Arrows indicate SW-100 treatment.