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. Author manuscript; available in PMC: 2020 Mar 20.
Published in final edited form as: ACS Chem Neurosci. 2018 Dec 14;10(3):1679–1695. doi: 10.1021/acschemneuro.8b00600

Figure 7.

Figure 7

SW-100 selectively increases the levels acetylated α-tubulin in the hippocampus of Fmr1−/− mice. Twenty mg/kg SW-100 was administered twice a day on days 1 and 2 and an additional injection was given on day 3 (1 h prior to cognition assessments) and another injection was given on day 4 (1 h prior to cognition assessments). (a) Basal levels of acetylated α-tubulin in the hippocampus of WT and Fmr1−/− mice. Data were normalized relative to the WT mice. Immunoblots from representative mice in each group, at 2 h after treatment, showing acetylated α-tubulin in the hippocampus of (b) WT mice and (c) Fmr1−/− mice. Data were normalized to the vehicle group (0 mg/kg). Graphs represent mean ± SEM; *p < 0.05 (a), **p < 0.01. (c) Compared to control condition (n = 6–10 per group).