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. Author manuscript; available in PMC: 2020 Mar 20.
Published in final edited form as: ACS Chem Neurosci. 2018 Dec 14;10(3):1679–1695. doi: 10.1021/acschemneuro.8b00600

Table 1.

Permeability Determination for 6–12, SW-100, and TubAa

pKa
 MDCK-MDR1 cell line
compd acidic basic Papp(A−B)
(10−6, cm/s)		 Papp(B−A)
(10−6, cm/s)		 efflux
ratio
SW-100 9.05 2.91  4.58  2.33 0.51
6 9.20 2.07  7.35  5.24 0.70
7 9.20 5.12 17.61 11.04 0.63
8 9.20 5.95  4.44 13.45 3.23
9 9.00 5.86  3.89 13.17 4.23
10 9.05 0.99  9.14  5.54 0.62
11 9.05 0.84 10.46 11.08 1.05
12 9.05 6.55  0.66  2.05 2.95
TubA 9.20 7.14  2.00 19.66 9.83
a

pKa values were obtained by Marvin Sketch version 18.5. MDCK-MDR1 cell line assays were carried out by Pharmaron, Inc. (Irvine, CA).